《科学》 2026年10月15日 · 中文解读
植物损伤感知免疫受体识别细胞壁糖类的分子机制
Glycan recognition by a plant damage-sensing immune receptor · P. Jiménez-Sandoval et al.
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这篇讲什么
西班牙与瑞士团队解析了拟南芥细胞壁损伤感知受体IGP1的晶体结构,发现它通过LRR结构域中高度选择性的糖结合口袋识别纤维素降解产生的纤维三糖。该受体并不直接触发完整免疫反应,而是提升免疫受体的表达水平,使植物在遭遇病原体时能更快、更强地启动防御。这一机制为通过强化损伤感知通路改良作物抗病性提供了新思路。
原文开头
Glycan recognition by a plant damage- sensing immune receptor Pedro Jiménez- Sandoval et al. INTRODUCTION: Plants are constantly exposed to microbes that attempt to invade their tissues. Their first line of defense is the cell wall—a protective layer that also serves as a sensor of damage. When pathogens attack, they release enzymes that break down cell wall components, generating small sugar fragments. These fragments act as danger signals, alerting the plant to potential infection. However, how plants detect these molecules and translate them into immune responses has remained poorly understood. RATIONALE: Among these danger signals are cellulose- derived fragments known as cello- oligomers. …
摘自《科学》(Science)2026年10月15日,P. Jiménez-Sandoval et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。

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