肠道隐窝中的计时机制：振荡信号动态保障肠道健康

Oscillating signal dynamics confer robust intestinal health Stephanie J. Ellis To maintain homeostasis, barrier epithelia—the body’s first line of defense—undergo constant, rapid turnover. This includes the inner surface of the mammalian intestine, where ongoing regeneration protects against daily wear and tear, preventing dangerous breaches and supporting gut health. The correct proportion of cell types is maintained throughout lifetimes, ensuring that form and function are preserved. Although the signaling pathways required for this balance are known, it has been unclear how their inputs are tuned to appropriately apportion cell fates (1–3). On page 289 of this issue, Weterings et al. …