晨间信号Morning Signal
《科学》 2026年10月15日 · 中文解读

植物如何识别免疫原性聚糖

How plants decode immunogenic glycans · Lisha Zhang and Thorsten Nürnberger
约 13 分钟Perspectives在小程序里点播,20 到 60 分钟做好
这篇讲什么
植物通过模式识别受体感知微生物释放的几丁质寡糖、壳聚糖和纤维素寡糖等聚糖信号,从而启动免疫反应。Gysel等人、Huang等人和Jiménez-Sandoval等人分别揭示了CHIP13、OsFID1和IGP1等受体的结构特征与识别机制,说明配体特异性和受体组装如何把免疫激活限定在微生物侵染的语境中。这些发现为工程化改造受体功能提供了结构基础。
原文开头
Animals and plants use conceptually similar immune systems to detect microbes and activate defenses. In both lineages, pattern recognition receptors (PRRs) perceive pathogen- or microbe-associated molecular patterns (PAMPs or MAMPs) and host-derived damage-associated molecular patterns (DAMPs). Whereas animals rely on specialized immune cells, plants harness individual cells expressing diverse PRRs (1). In the apoplast, which lies outside the plasma membrane and includes the cell wall, PRRs detect immunogenic fragments released from microbial proteins by plant hydrolytic enzymes. Conversely, pathogen-secreted enzymes can degrade constituents of the apoplast, generating DAMPs that activate immunity (2). On pages 298, 291, and 290 of this issue, Gysel et al. (3), Huang et al. (4), and Jiménez-Sandoval et al. …
摘自《科学》(Science)2026年10月15日,Lisha Zhang and Thorsten Nürnberger。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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