羽扇豆有毒喹诺里西啶生物碱合成的遗传基础

The genetic basis for the production of toxic quinolizidine alkaloids in lupins Davide Mancinotti, Hajar Golshadi Ghalehshahi, Isabella Kruse- Andersen, Louise Kjaerulff, Ting Yang, Dan Stærk, Fernando Geu- Flores* INTRODUCTION: Quinolizidine alkaloids (QAs) are specialized metabolites produced by several species of legumes, including the protein- rich pulses called lupins (Lupinus spp.). Given their bitter taste and anticholinergic toxicity, reducing alkaloid levels by breeding is crucial to meet food safety standards. However, the use of new breeding technologies is hampered by a limited understanding of the underlying biosynthetic pathway. The pathway starts with the amino acid lysine, and a few enzymes in the early and late stages have been discovered. …