《科学》 2026年10月8日 · 中文解读
光遗传学摘得诺贝尔生理学或医学奖
Lights, neurons, action! · Science News Staff
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三位科学家因开发出用光精确开关脑细胞的光遗传学方法,获得今年的诺贝尔生理学或医学奖。柏林洪堡大学的彼得·黑格曼与维尔茨堡大学的格奥尔格·纳格尔发现了对光响应的通道蛋白,斯坦福大学的卡尔·戴瑟罗斯随后将该基因导入啮齿动物脑细胞,造出毫秒级响应的光控开关。这一技术已帮助少数盲人恢复部分光感,并正在癫痫、疼痛等疾病中接受治疗试验。
原文开头
Three scientists who developed a way to precisely switch brain cells on and off with light have been honored with this year’s Nobel Prize in Physiology or Medicine. The method, known as optogenetics, has clarified nerve circuits in healthy and diseased brains. It has also been adapted to help a few blind people regain modest sensitivity to light and is being tested as a treatment for epilepsy, pain, and more. Peter Hegemann of the Humboldt University of Berlin and Georg Nagel of the Julius Maximilian University of Würzburg paved the way for the technique. In the 2000s, the pair discovered that a protein in the single-celled alga Chlamydomonas responds to light. …
摘自《科学》(Science)2026年10月8日,Science News Staff。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。

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