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《科学》 2026年10月8日 · 中文解读

罗莎琳德·富兰克林真的错过了DNA双螺旋吗?并没有

How did Rosalind Franklin miss the helix in her iconic DNA image? She didn’t · Tim Appenzeller
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科学史学家阿利斯泰尔·斯庞塞尔与晶体学家布莱恩·萨顿重新分析了罗莎琳德·富兰克林的实验笔记,指出她在拍摄著名的“51号照片”之前,就已从有缺陷的“49号照片”中识别出DNA的螺旋结构。她之所以对51号照片着墨甚少,是因为无需重复记录,而这张照片正是为发表而刻意重拍的。这一研究驳斥了詹姆斯·沃森暗示自己率先领悟螺旋结构的说法。
原文开头
“The instant I saw the picture my mouth fell open and my pulse began to race.” So wrote James Watson in The Double Helix: A Personal Account of the Discovery of the Structure of DNA, his controversial account of how he and Francis Crick deciphered the structure of DNA in 1953. The image, now known as photograph 51, showed an elegant, symmetrical pattern of spots formed by x-rays diffracted from strands of DNA—the fingerprint of the molecule’s helical structure. Rosalind Franklin, an x-ray crystallographer at King’s College London (KCL), had produced the image in the spring of 1952. But Watson’s 1968 book, amid other slights and sexist language directed at Franklin, implied the flash of insight was his alone. …
摘自《科学》(Science)2026年10月8日,Tim Appenzeller。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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