利用氧气活化的不对称酶促膦氢化反应

Yi Zhou, Yifei Ge, Wesley Harrison, Huimin Zhao* INTRODUCTION: Carbon–phosphorus (C–P) compounds are widely used in medicines, agriculture, and advanced materials. However, enzymatic C–P bond formation in nature is extremely rare. Chemical methods can construct these bonds through P- centered radicals but often require harsh oxidants or specially activated starting materials and provide limited selectivity. Enzymes could overcome these limitations by guiding highly reactive radical intermediates with precision. A biocatalytic method that directly incorporates common P compounds to alkenes would therefore provide a mild and selective route to value- added, structurally diverse products. RATIONALE: Molecular oxygen (O2) is an attractive, abundant oxidant, but its partial reduction generates reactive oxygen species (ROS) that usually damage enzymes and disrupt radical reactions. …