含PI(3,4)P2的高尔基体来源囊泡驱动线粒体融合

Golgi- derived vesicles containing PI(3,4)P2 drive mitochondrial fusion Sho Aki† and Mayuko Segawa† et al. INTRODUCTION: Mitochondria are double- membrane–bound organelles that generate adenosine triphosphate (ATP) and form a dynamic network remodeled by cycles of fusion and fission. These shape transitions are essential for organelle function, metabolic adaptation, mitochondrial quality control, and cell fate, and defects in these processes are associated with human disease. Although the functions of the core guanosine triphosphatases (GTPases) that drive mitochondrial dynamics are well established, these processes are now recognized to be coordinated by other organelles and regulated by local lipid signaling. However, beyond the endoplasmic reticulum (ER), whether and how other organelles, in particular, Golgi- derived vesicles, regulate mitochondrial fusion remain understudied. …