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《新科学家》 2026年9月26日 · 中文解读

消失在痴呆症中

Disappearing into dementia · Carissa Wong
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这篇讲什么
罗伯特·科尔克的新书《消失的家族》讲述了宾夕法尼亚一个家族的故事:由于MAPT基因突变,家族成员有50%的概率遗传额颞叶痴呆,芭比的母亲和九个兄弟姐妹中有五人已逐渐“消失”。书中穿插了科学家如何通过极端病例揭示额颞叶功能的历史,并记录了芭比推动治愈研究的努力。今年7月一项400人试验显示,药物diranersen能降低tau蛋白水平并减缓认知衰退,为这类家庭带来希望。
原文开头
The story of a family that loses many of its members young to an inherited condition explores grief, enduring love and medical hope, says Carissa Wong BY THE time Barb got the letter with her test results, she had already seen her mother and five of her nine siblings gradually “disappear”. From their forties, they had started to act in unusual ways: they had ignored their children, become unrecognisable to their spouses and lost all sense of social norms. It made her very nervous about her own fate. She knew she had a 50 per cent chance of inheriting the same gene for dementia that had upended the lives of her loved ones. …
摘自《新科学家》(New Scientist)2026年9月26日,Carissa Wong。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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