可编程设计合成植物免疫受体以识别病原体蛋白

Haocheng Zhu†, Dandan Jiang†, Qiao Zhang†, Kang Zhang, Kevin Tianmeng Zhao, Jin-Long Qiu, Caixia Gao* INTRODUCTION: Current resistance breeding strategies rely heavily on resistance (R) genes, most of which encode intracellular nucleotide-binding leucine-rich repeat (NLR) immune receptors. However, this resistance is frequently overcome by rapidly evolving pathogens. To counter newly adapted pathogens, additional NLR receptors must be identified and introgressed into crops to develop new varieties, but this process is constrained by the limited diversity and slow discovery of natural R genes. By contrast, designing custom plant immune receptors offers a more efficient and potentially universal strategy for conferring crop resistance against emerging pathogens. Nevertheless, a scalable platform for the efficient design of plant immune receptors remains elusive. …