丘脑NRXN1介导的输入驱动人类皮层祖细胞兴奋性神经发生

Claudia V. Nguyen1, Antoni Martija1, Daniel C. Jaklic1, Rista White1, Marty G. Yang1, Patricia R. Nano1, Jose A. Soto1, Jessenya Mil1, Dakshesh Rana1, Jacqueline M. Martin2, Hunter E. Schweiger3,4, Sebastian Hernandez3,5, Elisa Fazzari1, Yu Liu6,7, Jack M. Parent6,7,8, Mohammed A. Mostajo-Radji3, Daniel H. Geschwind2,9,10, Aparna Bhaduri1* The human cerebral cortex develops through coordinated signals from within the cortex and from other brain regions, including the thalamus. However, how thalamic neuronal projections influence early human cortical development remains less well-understood. In this study, we fused cortical and thalamic organoids to investigate how thalamic input shapes the maturation of human cortical cells. Using single-nuclei RNA-sequencing and cellular imaging, we found that thalamic input increases the production of cortical excitatory neurons. …