丘脑NRXN1介导的输入驱动人类皮层祖细胞兴奋性神经发生

Claudia V. Nguyen, Antoni Martija, Daniel C. Jaklic, Rista White, Marty G. Yang, Patricia R. Nano, Jose A. Soto, Jessenya Mil, Dakshesh Rana, Jacqueline M. Martin, Hunter E. Schweiger, Sebastian Hernandez, Elisa Fazzari, Yu Liu, Jack M. Parent, Mohammed A. Mostajo- Radji, Daniel H. Geschwind, Aparna Bhaduri* INTRODUCTION: Thalamocortical afferents (TCAs) influence cortical arealization, laminar specification, and maturation, but how extrinsic thalamic inputs shape human cortical neurogenesis remains poorly understood. In primates, cortical development includes expanded progenitor populations such as outer radial glia (oRG), early thalamic innervation, and prolonged upper- layer excitatory neurogenesis. Because these features are difficult to disentangle in vivo, the mechanisms by which thalamic signals regulate progenitor behavior and cortical cell fate have remained unclear. …