人类海马体衰老过程中的表观遗传与三维基因组重编程

Nathan R. Zemke et al. INTRODUCTION: Aging is the strongest risk factor for neurodegenera- tive disease and is accompanied by memory decline and chronic inflammation in the brain. The hippocampus, a region essential for learning and memory, is particularly vulnerable to aging. Prior studies have identified age- related shifts in gene expression, including increased inflammatory signaling and reduced synaptic function, implicating transcriptional dysregulation in brain aging. However, gene expression alone provides an incomplete view. It remains unclear how epigenetic regulation and higher- order genome organization change across cell types and how these changes drive hippocampal dysfunction. Defining these molecular alterations is critical for understanding cognitive decline and disease susceptibility. …