HNF1B通过前馈环路整合信号驱动慢性肾病进展

Full article and list of author affiliations: https://doi.org/10.1126/ science.aea3219 Pierre Isnard, Munevver Parla Makinistoglu, Michel Leibovici, Jonathan Levinsohn, Nicolas Zimmermann, Camille Cohen, Serge Garbay, Clement Nguyen, Deborah Gaglioti, Magali Chiral, Armelle Grevellec-Christophorou, Arianna Fiorentino, Dorien J.M. Peters, Evelyne Fischer, Frank Bienaimé, Katalin Susztak, Fabiola Terzi*, Marco Pontoglio* INTRODUCTION: Chronic kidney disease (CKD) affects more than 10% of the global population and is characterized by an inexorable decline in renal function, regardless of the triggering insult. A defining feature of CKD is its self-perpetuating nature: Once established, kidney injury progresses even when the original trigger has resolved. Identifying the molecular circuits that maintain this pathological state is essential to understand disease progression and to design effective therapeutic strategies. …