表达自我：大脑中超过3000个基因的表达在男女之间存在差异

The brain’s expression of more than 3000 genes differs between men and women Jessica Tollkuhn1 and S. Marc Breedlove2 Men and women show striking differences in risk, prevalence, and progression of many psychiatric and neurological disorders. For example, schizophrenia, attention deficit hyperactivity disorder (ADHD), and Parkinson’s disease are more common in men, whereas mood disorders and Alzheimer’s disease affect women more frequently. Understanding the molecular mechanisms underlying such sex differences could help to identify the pathways that promote resilience to disease and thus might be targeted therapeutically. On page 274 of this issue, DeCasien et. al. (1) report a systematic examination of how sex influences neural gene expression at the single-cell level. …