必需氨基酸缺乏时神经元与激素肠道-大脑反应的复杂相互作用

Boram Kim1†, Seongju Lee1†, Hyeyeon Bae1,2, Shinhye Kim2, Jong-Hoon Won1,2, Dongwoo Kim1,2, Byungkwon Jung2, Makoto I. Kanai3‡, Sung-Eun Yoon4, Yangkyun Oh5*, Won-Jae Lee6*, Greg S. B. Suh1,2,4,7* A balanced intake of nutrients is essential for the survival and maintenance of organisms. Although the proportional requirements for macronutrients vary across species, they are tightly regulated within a given species. Animals use both preingestive (taste) and postingestive systems that detect macronutrients in the environment and help maintain appropriate internal nutrient balance. Proteins are composed of essential amino acids (EAAs) and nonessential amino acids (NEAAs). Substantial progress has been made to understand how the taste system detects amino acids. …