交感神经-嗜酸性粒细胞轴介导心理应激加剧皮肤炎症

A sympathetic- eosinophil axis orchestrates psychological stress to exacerbate skin inflammation Full article and list of author affiliations: https://doi.org/10.1126/ science.adv5974 Jiahe Tian†, Yudian Cao†, Yilei Li†, Junlong Sun, Cheng Zhan, Wei Ni, Yongjun Zheng, Yanqing Wang, Shenbin Liu* INTRODUCTION: Psychological stress is a well- established exacerbat- ing factor for atopic dermatitis (AD), capable of worsening inflam- mation through complex interactions among the nervous, endocrine, and immune systems. Stress hormones can directly compromise the skin barrier, promote inflammation, and intensify the sensation of itch. Scratching in response to itch further damages the skin, creating a self- perpetuating cycle of inflammation and psychological distress. Consequently, stress management is consid- ered an integral component in the comprehensive management of AD. …