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Human studies test noninvasive “temporal interference” stimulation in epilepsy and other diseases JENNIE ERIN SMITH I n 2017, physicist Nir Grossman made a discovery that prom- ised a versatile new way to manipulate the living brain. Working in mice, he and his collabo- rators applied two high-frequency electrical currents to the skull. At the spot in the rodents’ brains where the currents collided, the electric field altered neural activity. Other noninvasive methods typically reach no further than the cortex, the brain’s outer layer. The new approach, called temporal interfer- ence (TI) stimulation, offered access to deep-brain areas previously only targetable with surgery. ratio of the interfering currents, investigators can steer the signal to different brain areas. …
摘自《科学》(Science)第391卷 第6791期 · 2026年3月19日,Jennie Erin Smith。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。