Spatial and morphological organization of mitochondria in neurons across a connectome
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Full article and list of author affiliations: https://doi.org/10.1126/ science.ads6674 Garrett Sager, Paul Pfeiffer, Heng Wu, Fabian Pallasdies, Robert Gowers, Snusha Ravikumar, Elizabeth Wu, Daniel Colón- Ramos, Susanne Schreiber*, Damon A. Clark* INTRODUCTION: Neurons rely on mitochondria for energy produc- tion, calcium buffering, and synaptic function, yet the principles governing their organization across whole neural circuits remain unclear. Advances in electron microscopy (EM) connectomics now allow for the visualization of subcellular structures within complete neural networks, offering an unprecedented opportunity to examine how mitochondrial morphology and positioning relate to neuronal architecture and function. …
摘自《科学》(Science)第391卷 第6791期 · 2026年3月19日。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。