跨越时间的疼痛

Two brain circuits facilitate the interaction between chronic pain and time Simon Beggs1 and Paul W. Frankland2,3,4,5,6 Pain is classically defined as a sensory experience, yet it also engages emotional and cognitive processes (1). When pain becomes chronic—persists or recurs beyond 3 months from injury—it is frequently accompanied by disability and emotional dysregulation (2). Among these comorbidities, depression, anxiety, and sleep disorders are the most prevalent, yet the mechanistic relationships linking pain chronic- ity to these affective consequences remain poorly understood. On page 1235 and 1236 of this issue, Wei et al. (3) and Ding et al. (4), respectively, report evidence of pain-related brain regulation at two opposite ends of the temporal spectrum. Wei et al. …