DNA-蛋白质交联通过cGAS-STING通路驱动早衰和胚胎致死

Full article and list of author affiliations: https://doi.org/10.1126/ science.adx9445 Ines Tomaskovic†, Cristian Prieto-Garcia†, et al. INTRODUCTION: DNA-protein cross-links (DPCs) are highly toxic lesions in which proteins become covalently attached to DNA, blocking essential processes such as replication and transcription. To maintain genome stability, cells rely on specialized repair mechanisms that remove DPCs. The protease SPRTN was the first enzyme identified to resolve these lesions by cleaving the protein component from DNA. Although SPRTN’s function has been well-documented during DNA replication, its role in other phases of the cell cycle remains less understood. Importantly, inherited inactivating mutations in SPRTN cause Ruijs-Aalfs progeria syndrome (RJALS), a rare disorder marked by premature aging and early-onset liver cancer. …