哺乳动物小脑发育中基因调控的演化

Full article and list of author affiliations: https://doi.org/10.1126/ science.adw9154 Ioannis Sarropoulos†, Mari Sepp†, Tetsuya Yamada† et al. INTRODUCTION: The mammalian cerebellum has experienced many evolutionary innovations, but their molecular basis remains elusive. Most phenotypic changes are thought to be driven by mutations in cis- regulatory elements (CREs) such as enhancers and promoters, which control gene expression in a cell type–specific manner. However, the fast CRE evolution and our limited understanding of how DNA sequences encode regulatory activity have hindered our ability to study regulatory innovations. …