植物器官衰老驱动DNA甲基化衰减程序

Full article and list of author affiliations: https://doi.org/10.1126/ science.adu2392 Dawei Dai, Ken Chen, Jingwen Tao, Ben P. Williams* INTRODUCTION: DNA methylation is a dynamic epigenetic modifi- cation to the genome of diverse eukaryotes, including plants, animals, and fungi. In mammals and humans, DNA methylation has emerged as a leading biomarker for biological age, yet the molecular mechanisms that contribute to these changes remain poorly understood. Plants share many similarities with mammals in their DNA methylation patterning, but the relationship between aging and epigenetic dynamics in plants is poorly understood. RATIONALE: Owing to the limitations of mammalian model species and cell culture systems, the dissection of molecular mechanisms underpinning epigenetic aging dynamics is challenging. …