重新思考衰老的遗传力

The genetic contribution to human longevity is greater than previously thought Daniela Bakula and Morten Scheibye-Knudsen Life span varies strikingly across the tree of life. Baker’s yeast survive for days, fruit flies for weeks to months, bowhead whales for more than two centuries, and bristlecone pines for millennia (1). Comparative studies have uncovered conserved biological mechanisms that regulate aging (2), leaving little doubt that genetics places strong constraints on how long organisms live. Nevertheless, classical aging experiments in animals show that there is considerable variability in life span, even among isogenic littermates, indicating that there’s more to aging than genetics (3). …