衰老导向纳米疗法改善纤维化并克服癌症免疫排斥

Clemens Hinterleitner†, Valentin J. A. Barthet† , Hailey V. Goldberg†, et al. INTRODUCTION: Fibrosis, a common consequence of chronic tissue injury, involves excessive extracellular matrix deposition, disruption of tissue architecture, and immunosuppressive remodeling. These processes impair both organ function and immune surveillance. Fibrosis is also linked to cancer; many solid tumors either arise within preexisting fibrotic tissues or induce fibrosis- like stromal remodeling, creating barriers that restrict T cell infiltration and diminish the efficacy of immunotherapies. Cellular senescence, an antiproliferative program linked to tissue remodeling, is an important driver of fibrosis. Although senescent cells can support tissue repair and suppress carcinogenesis, persistent accumulation of senescent cells promotes fibrosis and immune dysfunction. …