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《科学》 第392卷 第6797期 · 2026年4月30日 · 中文解读

AI能否简化生命字母表?

Can AI simplify the alphabet of life? · C. Sanfiorenzo and K. Wang
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这篇讲什么
本文报道了研究人员利用生成式人工智能设计出仅含19种氨基酸的功能性细菌蛋白质,并探讨了简化生命遗传字母表的可能性。
原文开头
Generative AI design yields functional proteins with only 19 amino acids Charles Sanfiorenzo and Kaihang Wang L ife can be imagined as a language, with genomes as books and proteins as sentences that relay messages within living cells. Unlike in human languages, the alphabet of life seems immutable. Across living organisms, proteins are composed of the same 20 canonical amino acid (cAA) letters. Could one of these cAA letters be removed from all protein sentences in an organism while keeping the sentences coherent? On page 487 of this issue, Liu et al. (1) report that generative artificial intelligence (AI) can be used to design functional bacterial proteins without the amino acid isoleucine. …
摘自《科学》(Science)第392卷 第6797期 · 2026年4月30日,C. Sanfiorenzo and K. Wang。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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