选择性自噬微调植物免疫以促进病毒感染期间的细胞存活

Full article and list of author affiliations: https://doi.org/10.1126/science.adu9554 Marion Clavel et al. INTRODUCTION: Positive-sense single-stranded RNA (+ssRNA) viruses assemble viral replication complexes (VRCs) by remodeling host endomembranes and organelles. This remodeling can disrupt organelle integrity and generate stress signals that intersect with cellular quality control and immune signaling. Selective autophagy is a quality control pathway that targets specific damaged or superfluous cellular components for lysosomal or vacuolar degradation, but how systemic viral infection engages selective autophagy and what it contributes to disease outcomes remain unclear. RATIONALE: We asked how +ssRNA virus infection induces selective autophagy, how cargo selectivity is specified, and whether autophagy limits viral accumulation or supports host fitness during systemic infection. …