细菌中全球代谢通量与蛋白质组分配的脱偶联

Full article and list of author affiliations: https://doi.org/10.1126/ science.aeb6410 Ryan Thiermann†, Jin Yang†, Aniket Zodage†, Fukang She†, Danny K. Fung, Taylor Rytlewski, Farshad Abdollah- Nia, Fangzhou Xiao, John T. Sauls, Sarah Cox, Zulfar Ghulam- Jelani, Victoria Castillo, Quinn A. Paulsen, David M. Stevenson, Daniel Amador- Noguez, James R. Williamson, Jue D. Wang*, Suckjoon Jun* INTRODUCTION: Bacterial growth and adaptation depend on how cells allocate limited biosynthetic resources. In Escherichia coli, this process is coordinated by guanosine tetraphosphate and pentaphosphate, collectively termed (p)ppGpp, which are alarmones that link amino acid availability to ribosome production and protein composition. This regulatory logic underlies the widely accepted optimal growth model, in which metabolic flux and proteome allocation are tightly coupled to maximize biosynthetic output. …