CD4+ T细胞通过IL-3和TNF依赖性血管损伤抑制肿瘤生长

CD4+ T cells impair tumor growth through IL-3 and TNF-dependent vascular damage Qiaoshi Lian1†, Jia Nie2†*, Jatinder Singh3, Qiang Chen2, Jennifer Matta4, Waipan Chan1, Mariah Balmaceno-Criss2, Melanie S. Vacchio2, Weiming Yu1, Alexander D. Clark2, Elijah Edmondson4, Michael C. Kelly3, Ronald N. Germain1‡*, Rémy Bosselut2‡* Most cancer immunotherapy strategies are focused on direct tumor killing by immune cells, especially T lymphocytes. Clinical and conceptual limitations of these approaches create a need for additional strategies. We identified a tumor stroma–targeting mechanism in which tumor antigen–specific CD4+ T cells inhibit tumor growth through myeloid cell and tumor necrosis factor (TNF)–dependent vascular damage. …