从原肠胚形成到器官发生的亚细胞分辨率全胚胎空间转录组学

Full article and list of author affiliations: https://doi.org/10.1126/ science.adt3439 Yinan Wan*, Jakob El Kholtei†, Ignatius Jenie†, Mariona Colomer-Rosell, Jialin Liu, Qinghua Zhang, Joaquin Navajas Acedo, Lucia Y. Du, Mireia Codina-Tobias, Mengfan Wang, Wei Zheng, Edward Lin, Tzy-Harn Chuang, Oded Mayseless, Ahilya Sawh, Susan E. Mango, Guoqiang Yu, Bogdan Bintu*, Alexander F. Schier* INTRODUCTION: Visualizing gene expression patterns has been essential to reveal the principles that underlie vertebrate development. Most analyses have been based on relatively small numbers of genes or rest on single-cell genomics approaches with limited spatial information. It has therefore been difficult to systematically study the full diversity and dynamics of vertebrate gene expression patterns and dissect their link to genomic elements and the movement of cells. …