多尺度泛基因组图谱助力混合倍性甘蔗物种的基因组解析

Full article and list of author affiliations: https://doi.org/10.1126/ science.adx1616 Yumin Huang†, Yixing Zhang†, Qing Zhang†, Gui Zhuang, Chunjia Li, Baiyu Wang, Ruiting Gao, Yi Xu, Yiying Qi, Xiuting Hua, Huihong Shi, Qiutao Xu, Wei Yao, Xinlong Liu, Yongwen Qi, Baoshan Chen, Muqing Zhang, Ray Ming, Haibao Tang*, Jisen Zhang* INTRODUCTION: Modern sugarcane cultivars (Saccharum spp.) harbor exceptionally complex genomes shaped by interspecific hybridization, extreme and uneven polyploidy, aneuploidy, and abundant repeats. These features obscure haplotypes and allele dosage, complicating genetic research and breeding. A single linear reference cannot accommodate variation in ploidy, chromosome number, or introgressed backgrounds. RATIONALE: Graph genomes provide a compact, coordinate-consistent representation of alternative haplotypes and ploidy states, enabling allele-aware alignment, variant discovery, and cross-ploidy comparisons. …