DNA折纸疫苗编程抗原聚焦的生发中心

Anna Romanov1,2†, Grant A. Knappe1,3‡, Larance Ronsard4‡, Christopher A. Cottrell5,6,7, Yiming J. Zhang1,2, Heikyung Suh2,5, Lauren Duhamel1,2, Marjan Omer1,8, Asheley P. Chapman2,5, Katie Spivakovsky1, Patrick Skog5,6,7, Claudia T. Flynn6,7, Jeong Hyun Lee6, Oleksandr Kalyuzhniy5,6,7, Alessia Liguori5,6,7, Molly F. Parsons1§, Vanessa R. Lewis2, Josue Canales9, Boris Reizis9, Ryan D. Tingle5,6,7, Torben Schiffner5,6,7, William R. Schief5,6,7,10, Daniel Lingwood4, Mark Bathe1,11,12*, Darrell J. Irvine1,2,4,5,7,13* Priming rare subdominant precursor B cells in germinal centers (GCs) is a central goal of vaccination to generate broadly neutralizing antibodies (bnAbs) against HIV. Multivalent immunogen display on protein nanoparticle scaffolds can promote such responses, but it also generates scaffold-specific B cells that could theoretically limit bnAb precursor expansion in GCs. …