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《科学》 第391卷 第6785期 · 2026年2月5日 · 中文解读

卵巢基质作为治疗靶点

The ovarian stroma as a therapeutic target · Francesca E. Duncan and Elnur Babayev
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这篇讲什么
本文探讨了通过抗纤维化药物调节卵巢基质以促进卵泡发育,可能改善卵巢功能不全和年龄相关不孕症的治疗前景。
原文开头
A drug with antifibrotic properties may improve fertility Francesca E. Duncan1,2 and Elnur Babayev1 T he follicle is the functional unit of the ovary. Follicles produce hormones and eggs that regulate the menstrual cycle and fer- tility, respectively . Female mammals are born with a finite number of follicles (ovarian reserve), which dictates their re- productive life span. The ovarian reserve decreases with age, and the trajectory of this loss depends on genetics, autoimmune and metabolic conditions, exposure to environmental contaminants, and unintended effects of medical treatments. In women with premature ovarian insufficiency (POI), ovarian function is lost before age 40. …
摘自《科学》(Science)第391卷 第6785期 · 2026年2月5日,Francesca E. Duncan and Elnur Babayev。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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