Transcription factor Etv3 controls the tolerogenic function of dendritic cells · Unknown
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Full article and list of author affiliations: https://doi.org/10.1126/ science.ads1246 Nicholas M. Adams*, Daniel Martinez-Krams, Eduardo Esteva, Ai C. Ra, Allegra Iliadi Alexiou, Hua Jin, Tae Jin Yun, Rayan Sleiman Tellaoui, Tenny Mudianto, Emily Vollmer, Ekaterina Novikova, Yanjun Tan, William Huntley, Oleg Krichevsky, Igor Dolgalev, Peter Izmirly, Jill P. Buyon, Andre L. Moreira, Amanda W. Lund, Boris Reizis* INTRODUCTION: Dendritic cells (DCs) are immune sentinels that can directly recognize pathogens. During immune responses, DCs undergo maturation, during which they up-regulate the chemokine receptor CCR7 and migrate to regional lymph nodes, where they can initiate pathogen-specific T cell responses. In the absence of infection, DCs undergo pathogen-independent (homeostatic) maturation, which also leads to their CCR7-dependent migration to lymph nodes. …
摘自《科学》(Science)第391卷 第6786期 · 2026年2月12日,Unknown。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。