休息以修复：神经元活动如何影响髓鞘损伤

To repair or degenerate? In the central nervous system, myelin is produced by oligodendrocytes and forms an insulating sheath around the axons of neurons. Damage to myelin manifests as swelling; over time, these swellings can either remain stable, grow, or shrink. In zebrafish models of demyelination, activation of voltage-gated sodium channels increases neuronal activity and exacerbates myelin swelling, demyelination, and oligodendrocyte death. Blocking sodium channels reduces swelling, promotes myelin repair, and can rescue the oligodendrocyte. unlike previous studies that highligh- ted maladaptive increases in myelin, the authors have established the principle that neuronal activity can promote myelin loss in the acute period after injury. The implications of these findings are far-reaching. …