晨间信号Morning Signal
《科学》 第391卷 第6781期 · 2026年1月8日 · 中文解读

绘制骨感觉神经回路图谱揭示骨折愈合所需的神经营养信号

Mapping somatosensory afferent circuitry to bone identifies neurotrophic signals required for fracture healing
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该研究通过单细胞转录组学绘制了支配小鼠长骨的背根神经节神经元图谱,并发现成纤维细胞生长因子9(FGF9)是骨折修复的关键调节因子。
原文开头
Full article and list of author affiliations: https://doi.org/10.1126/ science.adr9608 Mingxin Xu, Zhao Li, Neelima Thottappillil, Masnsen Cherief, Manyu Zhu, Xin Xing, Mario Gomez- Salazar, Chunbao Rao, Sowmya Ramesh, Juliet M. Mwirigi, Ishwarya Sankaranarayanan, Diana Tavares- Ferreira, Chi Zhang, Xue- Wei Wang, Mary Archer, Yun Guan, Robert J. Tower, Patrick Cahan, Theodore J. Price, Thomas L. Clemens, Aaron W. James* INTRODUCTION: The profound pain accompanying bone fracture is mediated by somatosensory neurons, which also appear to be required to initiate bone regeneration. Primary somatosensory neurons comprise a diverse subset of neurons, which communicate information about the external environment and internal state to the central nervous system, enabling perception and reaction to a wide range of stimuli including pain. …
摘自《科学》(Science)第391卷 第6781期 · 2026年1月8日。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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