Mapping somatosensory afferent circuitry to bone identifies neurotrophic signals required for fracture healing
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Full article and list of author affiliations: https://doi.org/10.1126/ science.adr9608 Mingxin Xu, Zhao Li, Neelima Thottappillil, Masnsen Cherief, Manyu Zhu, Xin Xing, Mario Gomez- Salazar, Chunbao Rao, Sowmya Ramesh, Juliet M. Mwirigi, Ishwarya Sankaranarayanan, Diana Tavares- Ferreira, Chi Zhang, Xue- Wei Wang, Mary Archer, Yun Guan, Robert J. Tower, Patrick Cahan, Theodore J. Price, Thomas L. Clemens, Aaron W. James* INTRODUCTION: The profound pain accompanying bone fracture is mediated by somatosensory neurons, which also appear to be required to initiate bone regeneration. Primary somatosensory neurons comprise a diverse subset of neurons, which communicate information about the external environment and internal state to the central nervous system, enabling perception and reaction to a wide range of stimuli including pain. …
摘自《科学》(Science)第391卷 第6781期 · 2026年1月8日。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。