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《科学》 2026年10月1日 · 中文解读

高血压通过神经内分泌信号加速骨关节炎

Hypertension fuels osteoarthritis through neuroendocrine signaling · S.-J. Kim et al.
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这篇讲什么
韩国研究团队结合全国队列数据与两种高血压小鼠模型,发现高血压会加剧骨关节炎的进展。骨关节炎软骨细胞会上调精氨酸加压素受体AVPR1A,使循环中升高的加压素得以激活分解代谢信号,加速软骨破坏。遗传敲除或关节内药物阻断AVPR1A可防止高血压诱导的软骨退变,提示该通路是潜在治疗靶点。
原文开头
Su- Jin Kim†, Hyo- Eun Kim†, Ki- Ho Chung, Gyuseok Lee, Ka Hyon Park, Young- Gwon Kim, Mangeun Kim, Weon- Young Choi, Soo- Chang Joo, Hae Jin Kee, Seung- Hee Kwon, Jong- Keun Seon, Gun- Woo Lee, Yoonkyung Won, Jeong- Tae Koh, Jin Han, Jang- Soo Chun*, Je- Hwang Ryu* INTRODUCTION: Osteoarthritis (OA), the leading cause of disability among older adults, has long been considered a disease driven primarily by mechanical wear and tear. However, accumulating evidence indicates that OA is also influenced by systemic metabolic, endocrine, and vascular factors. Hypertension, which is highly prevalent in aging populations, is associated with an increased OA risk and greater severity. …
摘自《科学》(Science)2026年10月1日,S.-J. Kim et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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