17个小鼠ASD风险突变品系的转录组图谱解析为两种分子亚型

Fig. 1. A transcriptomic atlas of 17 mouse lines carrying ASD- risk mutations resolves into two molecular subtypes. (A) Cohort composition. Schematic of the 17 ASD- risk mutation lines, color coded by canonical function (turquoise, synaptic; blue, gene- regulatory; magenta, signaling). For each line, wild- type (WT) and mutant males and females were either vehicle- treated or exposed to fluoxetine or lithium through maternal milk from postnatal day P3 to P25. In total, 1008 mice (∼5 mice per group across 204 line × genotype × sex × treatment groups) were profiled. Mouse details are shown in fig. S1. (B) Experimental workflow. Prefrontal cortices harvested at P25 underwent bulk RNA- seq. …