EGFR T790M：一种在美国特定亚人群中富集的高风险、肺特异性易感等位基因

Fig. 5. The most common haplotypes containing the EGFR T790M variant that are shared among EGFR T790M carriers (n = 641). Red dotted lines indicate the range of the most common haplotype spanning 51.5 to 75.2 Mb (11.76 cM), and green lines indicate the range of the EGFR locus. as BRCA1 and illustrates how deleterious alleles can persist and expand through founder effects and drift. Haplotype-based dating estimates suggest that EGFR T790M propagated as recently as the early 19th century (circa 1803), raising the question of how a newly emergent allele could attain such relatively elevated frequency in a short evolutionary time frame. …