多细胞器特征图谱揭示组织中的细胞状态多样性与代谢适应

Raghabendra Adhikari†, Alexander Hillsley†, Alana Dowdell Johnson, Shihong Max Gao, Isabel Espinosa-Medina, Jan Funke, Daniel Feliciano* INTRODUCTION: The cells that make up our organs are not all identical; even within the same tissue, cells can adopt different functional states, performing specialized tasks that complement each other and adapting to changing conditions. Mapping this diversity has relied primarily on profiling gene activity, which captures only one layer of cellular organization. However, many core functions are executed by organelles—internal cellular compartments such as mitochondria, which generate energy, and lipid droplets, which store fat—whose shape, abundance, and arrangement directly reflect and influence what a cell is doing. …