细胞疗法挽救晚期脑癌儿童

Alice Klein Not all brain cancers (dark red) respond to standard treatments FOUR children with traditionally incurable brain cancers are still alive years after receiving an experimental immune- boosting cell therapy in a clinical trial. Three of them even display no evidence of disease. The experimental treatment, called tumour-associated antigen (TAA) T-cell therapy, was given to 33 children and young adults with either newly diagnosed diffuse intrinsic pontine glioma (DIPG), a highly aggressive form of brain cancer, or other brain tumours that hadn’t responded to standard treatments. The trial focused on these tumour types because “they’re universally fatal, there’s nothing else for them”, says team member Catherine Bollard, also at Children’s National Hospital. …