Artificial hibernation reveals synaptic engram architecture associated with memory retention · Y. J. Lin et al.
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Y. J. Lin1†, A. Takahashi- Nakazato1†, K. Tsutsumi2†, T. Takahashi2,3,4†‡, D. Mercier1, H. Ashitomi1, M. C. Chiang1, M. Haberl5, M. Uytiepo6,7§, A. Maximov6,7, Y. Makino2, T. Nemoto3,4,8, R. Enoki3,4,8, A. Hirano9,10,11, K. Soga2, S. Looprasertkul12,13¶, N. Ohno13,14, Y. Kubota15, T. Sakurai9,10,11, K. Z. Tanaka1* Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal representations after memory formation suggest alternative possibilities. to elucidate the structural trace underlying memory retention, we used a mouse model of artificial hibernation. During hibernation, hippocampal neurons exhibited a substantial reduction in their activity and an extensive elimination of dendritic spines and synapses. …
摘自《科学》(Science)第393卷 第6812期 · 2026年8月13日,Y. J. Lin et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。