晨间信号Morning Signal
《科学》 第393卷 第6812期 · 2026年8月13日 · 中文解读

丘脑皮层回路编码感觉历史偏差

A thalamocortical circuit encoding deviations from sensory history · Y. N. Leow et al.
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这篇讲什么
本文介绍了一项关于丘脑外侧后核(LP)与前扣带回皮层(ACC)通路的研究,该通路通过对比当前与近期感觉证据来影响决策更新。
原文开头
Yi Ning Leow1,2,3, Arundhati Natesan1, Alexandria Barlowe1, Sofie Ährlund- Richter1, Tianyu (Cindy) Luo2, Mehrdad Jazayeri2,4, Mriganka Sur1,2* Prior expectations guide attention and support perceptual filtering during decision- making. In mice performing a visual discrimination task, choices depended on trial- by- trial differences between consecutive stimuli (|ΔDir|). We hypothesized that thalamic lateral posterior (LP; rodent pulvinar) projections to prefrontal areas such as the anterior cingulate cortex (ACC), previously implicated in selective attention and predictive processing, could support history- dependent evaluation of current sensory evidence. In this work, we report that optogenetic manipulations of LP- ACC axons disrupted history- dependent evaluation of current sensory evidence, producing |ΔDir|- dependent choice biases. …
摘自《科学》(Science)第393卷 第6812期 · 2026年8月13日,Y. N. Leow et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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