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《科学》 第392卷 第6793期 · 2026年4月2日 · 中文解读

线粒体基因组串珠状排列的机制

Mitochondrial genomes on a string of pearls · J. van den Ameele and J. Prudent
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这篇讲什么
本文介绍了Landoni等人的研究,发现线粒体膜上瞬时的收缩(称为“串珠化”)能够将线粒体DNA分子分隔并规律排列,揭示了线粒体膜重塑与线粒体DNA生物学之间的机制联系。
原文开头
Transient membrane constrictions, or “pearling,” underlie the regular spacing of mitochondrial genomes Jelle van den Ameele1,2 and Julien Prudent1 Mitochondria are small, dynamic subcellular structures involved in many physiological functions, including energy production. They stand out among eukaryotic organelles because they have their own genome, a souvenir of their bacterial origin that remains essential for cellular energy metabolism. Mitochondrial DNA (mtDNA) is present in hundreds to thousands of copies per cell, assembled into nucleoprotein complexes called nucleoids. Nucleoids undergo continuous replication and turnover, are distributed regularly along the mitochondrial network, and usually contain only one or two mtDNA molecules (1). …
摘自《科学》(Science)第392卷 第6793期 · 2026年4月2日,J. van den Ameele and J. Prudent。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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