晨间信号Morning Signal
《科学》 第393卷 第6813期 · 2026年8月20日 · 中文解读

层分离小动脉网络介导的感觉模态特异性神经血管耦合

Modality-specific neurovascular coupling via layer-segregated arteriole networks · A. Malescot et al.
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该研究通过多尺度光学成像发现,小鼠皮层中不同感觉输入(触觉与痛觉)会选择性激活不同穿透深度的小动脉网络,从而产生层特异性的血流分布模式。
原文开头
Full article and list of author affiliations: https://doi.org/10.1126/science.aeb5077 Antoine Malescot, Milene R. Malheiros-Lima, Laurianne Zana, Michael C. Bennett, Éric Martineau, Franca Schmid, Ravi L. Rungta* INTRODUCTION: The brain continuously adjusts blood flow in response to elevations in neuronal activity through a process known as neurovascular coupling. These vascular responses form the basis of widely used brain imaging methods, such as functional magnetic resonance imaging (fMRI), which infer neuronal activity from local changes in blood oxygenation, flow, velocity, or volume. Although neurovascular signals are generally assumed to reflect neuronal activity in a consistent manner, different sensory experiences recruit distinct neural circuits across cortical layers. How these differences shape blood flow regulation within the brain remains poorly understood. …
摘自《科学》(Science)第393卷 第6813期 · 2026年8月20日,A. Malescot et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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