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《科学》 第393卷 第6813期 · 2026年8月20日 · 中文解读

追踪心脏修复中新生冠状动脉侧支形成的起源

Tracing the origins of de novo coronary collateral formation in cardiac repair · M. Zhang et al.
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这篇讲什么
该研究通过遗传谱系追踪发现,心肌梗死后新生冠状动脉侧支主要来源于毛细血管内皮细胞的动脉化,而非预先存在的动脉内皮细胞的重组。
原文开头
Tracing the origins of de novo coronary collateral formation in cardiac repair Full article and list of author affiliations: https://doi.org/10.1126/ science.ady3027 Mingjun Zhang†, Maoying Han†, Yangfeng Hou†, Zixin Liu†, Yilian Wang†, Xiuzhen Huang, Cheng Kiu Ho, Hang Qu, Qing- Dong Wang, Xin Ma, Kathy O. Lui*, Bin Zhou* INTRODUCTION: Coronary artery disease remains a leading cause of death worldwide. Acute occlusion of a coronary artery deprives downstream myocardium of oxygen and nutrients, precipitating myocardial infarction (MI). Coronary collateral arteries, which serve as natural bypass conduits between preexisting coronary artery branches, can restore perfusion to ischemic tissue and improve clinical outcomes. However, the cellular origin and molecular regulation of de novo collateral artery formation remain incom- pletely defined. …
摘自《科学》(Science)第393卷 第6813期 · 2026年8月20日,M. Zhang et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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