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《科学》 第393卷 第6813期 · 2026年8月20日 · 中文解读

RAD51稳定中性粒细胞胞外陷阱以区室化炎症

RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation · L. I. Tsansizi et al.
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本文研究了RAD51介导的DNA分支如何稳定中性粒细胞胞外陷阱(NETs)的结构,从而将炎症限制在局部组织,防止全身性炎症反应。
原文开头
Lorenza Iolanda Tsansizi†, Sophie Yihan Guan†, Iker Valle Aramburu, Rajvee Shah Punatar, Thomas J. Williams, Yihe Qiao, Anna Reed, Darius Armstrong- James, Stephen C. West, Venizelos Papayannopoulos* INTRODUCTION: Infection of tissues elicits local inflammation through the detection and release of inflammatory substances. Molecular and cellular mechanisms that help to maintain local tissue activation while preventing potentially pathogenic systemic activation remain unclear. Neutrophils are major antimicrobial phagocytes that are recruited to sites of infection and protect the host by releasing extracellular traps (NETs), weblike structures composed of chromatin and antimicrobial proteins that capture and neutralize pathogens. In addition to trapping microbes, NETs are proinflammatory, and dysregulated NET release can drive inflam- matory disease. …
摘自《科学》(Science)第393卷 第6813期 · 2026年8月20日,L. I. Tsansizi et al.。仅引用开头一小段供了解文章,版权归原刊所有,全文请阅读原刊。
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