迭代构建碳碳键：模块化合成方法拓宽化学可及性

A modular synthesis method could broaden the accessibility of chemistry Martin D. Burke1,2 Carbon atoms form strong links with each other to build the backbones of small molecules that are essential for society, such as medicines, materials, fertilizers, and a wide range of consumer products. For nearly two centuries, carbon atoms were linked through customized syntheses in which each reaction is selected from thousands of combinations of precursors and experimental conditions. This artisanal process heavily relies on specialized human skills, which makes it largely inaccessible to robots, artificial intelligence (AI), and nonexperts. Blocc chemistry, a modular approach to build small molecules from prefabricated building blocks (“bloccs”), has emerged from a new way to iteratively build carbon-carbon (C–C) bonds. …