哺乳动物小脑中AMPA受体-TARP复合物的结构与组织

Full article and list of author affiliations: https://doi.org/10.1126/ science.aeb3577 Alexander M. Scrutton†, Nayanika Sengupta†, Josip Ivica†, Imogen Stockwell, Sew Peak-Chew, Bishal Singh, Kunimichi Suzuki, Veronica T. Chang, Stephen H. McLaughlin, James M. Krieger, A. Radu Aricescu, Ingo H. Greger* INTRODUCTION: Excitatory synaptic transmission in the brain is mediated by ionotropic glutamate receptors—cation channels that open in response to glutamate released from presynaptic terminals. Their signaling is fundamental for higher cognitive processes such as learning and memory. Among them, AMPA receptors (AMPAR) are the most diverse as a result of their combinatorial assembly from four subunits, GluA1-4, which determine channel kinetics and calcium permeability. …