炎症记忆的表观遗传持久性由独特的DNA序列特征决定

Full article and list of author affiliations: https://doi.org/10.1126/ science.adz6830 Christopher J. Cowley†, Sairaj M. Sajjath†, Luis F. Soto-Ugaldi†, Mara Steiger, Samantha B. Larsen, Thomas Carroll, Douglas Barrows, Alexandra Mattei, Kevin A. U. Gonzales, Wei Wang, Kevin Li, Alexander Meissner, Helene Kretzmer, Dana Pe’er*, Elaine Fuchs* INTRODUCTION: Organisms adapt and learn from environmental stress. Plants that survive one pathogen broaden their resistance to others. Skin exposed to acute inflammation heals future wounds faster. Although evolutionarily advantageous, these memories can turn maladaptive, elevating chronic disease risks that, for skin, can mean psoriasis or atopic dermatitis; for lung, asthma and chronic respiratory diseases; and for intestine, inflammatory bowel disease. Increasing evidence suggests that inflammatory memories may also prime and perpetuate cancers. …